Research
Neural Microphysiological Systems
We design 3D tissue culture systems modeling the basic structure and function of neural tissues and circuits. We have used these models to study complex intercellular interactions with high relevance to drug discovery including demyelination, neurotoxicity, modulation of synaptic transmission, and pain sensation/analgesia. We continue to expand our repertoire through collaborative projects modeling viral neuroinvasion, neuro-immune interactions, and interconnectivity of brain region-specific neurospheroids.
Neural Tissue Engineering
We use advanced microfabrication techniques such as photolithography, bioprinting and additive manufacturing to develop 3D bioactive scaffolds with tunable physical, chemical, and biological properties to provide a biomimetic environment for stem cells to differentiate into mature neural cells, promoting axonal guidance and neurite outgrowth.
Neural Micro-Interfaces
We develop novel materials and systems to support the growth, homeostasis, and interrogation of neural tissues. We have developed functional, light-activated hydrogels that can direct the growth of axons in specific patterns within a 3D microenvironment. We are developing bio-electronic interfaces for recording and stimulating 3D neural tissues. This collaborative effort involves functional materials, microfabrication strategies, and electrophysiology.