Aryal, G. H.; Battle, C. H.; Grusenmeyer, T. A.; Zhu, M.; Jayawickramarajah, J. A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions. Chemical Communications 2016, 52, 2307-2310.
Abstract
A naphthalimide based fluorescent sensor displaying a significant increase in emission upon binding CB[7] with notable pH stability was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes. Previously unknown binders with moderate to strong affinities were discovered.
![Graphical abstract: A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5CC08350H&imageInfo.ImageIdentifier.Year=2016)