Rosenzweig, B. A.; Ross, N. T.; Tagore, D. M.; Jayawickramarajah, J.; Saraogi, I.; Hamilton, A. D. Multivalent Protein Binding and Precipitation by Self-Assembling Molecules on a DNA Pentaplex Scaffold. Journal of the American Chemical Society 2009, 131, 5020-5021.
Abstract
A supramolecular assembly containing an isoguanosine pentaplex with both a “protein-binding” face and a “reporter” face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.
