Aimee Twizeyimana

My name is Aimee Twizeyimana, I am from Rwanda. I am a PhD Candidate in Biomedical Engineering at Tulane University. My research is about vascular permeability in response to cancer signals, lipids, and ultrasound. My work focuses on determining how endothelial cells—particularly those of the blood-brain barrier—are affected by Low Density Lipoprotein (LDL), and how non-brain endothelial cells respond to breast cancer stimuli and ultrasound exposures. Specifically, I investigate whether permeability occurs via the paracellular route (through gaps between cells) or transcellular route (through the cells themselves). To distinguish between these pathways, I observe structural changes in the endothelial monolayer using confocal microscopy. I also use ECIS (Electrical Cell Impedance Sensing) to quantify real-time changes in cell barrier function and flow cytometry with Propidium Iodide to confirm that the cells remain viable after permeability is induced. My research aims to uncover how vascular leakiness can be modulated or prevented in diseases such as cancer and Alzheimer’s, and to enhance safety assessments for ultrasound-based therapies.

Outside the lab, I enjoy spending time with my family, exploring nature, reading books, and discovering new cities whenever I get the opportunity. I also like watching comedy, listening to music, and staying connected with friends and loved ones across different time zones. These moments help me recharge and stay balanced in the midst of academic life.

Curriculum Vitae

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